Ethyl vinyl ether → HCID 68823891, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1 g (4 mmol) of (16) and 0.46 ml (4.8 mmol) ethyl vinyl ether in 2 ml THF was stirred at room temperature in the presence of 201 mg (0.8 mmol) pyridinium p-toluenesulfonate (PPTS) for 4 hours. The mixture was stirred at 40° C. for 2 h and 0.46 ml (4.8 mmol) ethyl vinyl ether were added. After 6 hours at 40° C. the reaction the mixture was hydrolyzed with 3 ml of a saturated aqueous NH4Cl solution. After extraction with 50 ml diethyl ether the combined organic phases were washed (H2O), dried (Na2SO4) and the solvent was evaporated. Flash chromatography, using SiO2 (105 g) and n-pentane/diethyl ether=95:5 as eluent, afforded 215 mg (yield: 19%) of (26).

Provenance & Evidence