HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-methoxybut-2-ynoate → (S)-2-(4-Bicyclo[3.3.1]non-9-yl-phenoxymethyl)-5-methoxymethyl-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-methoxybut-2-ynoate | HCID 23249615 | — |
| Reactant | (S)-5-(4-bicyclo[3.3.1]non-9-yl-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine | HCID 68527534 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | (S)-2-(4-Bicyclo[3.3.1]non-9-yl-phenoxymethyl)-5-methoxymethyl-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one | HCID 25069825 | — |
Reaction Steps
The title compound was prepared from (S)-5-(4-bicyclo[3.3.1]non-9-yl-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine (see Example 20) and 4-methoxy-but-2-ynoic acid ethyl ester (see Example 106) employing the procedure described in Example 95. [α]D25 −14.55 (c 0.495, CHCl3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642603B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-daacd1db593242bfa705f48feac2e4e0 |
| Source note | uspto-grants-2014_02 |