3-(3-Fluoro-4-methoxyphenyl)propionic acid → HCID 68743427, compound

HRID 2378548Notes

Reaction equation

HRID 2378548 reaction equation
FC1C=C(CCC(O)=O)C=CC=1OC.[CH:15]1([O:20][C:21]2[C:26]([C:27]3[CH:36]=[CH:35][C:34]4[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=4)[CH:28]=3)=[CH:25][C:24]([CH2:37][CH2:38][C:39]([O:41]C)=[O:40])=[CH:23][C:22]=2[N:43](C)[C:44](=O)C(F)(F)F)[CH2:19][CH2:18][CH2:17][CH2:16]1>[OH-].[Na+]>[CH:15]1([O:20][C:21]2[C:26]([C:27]3[CH:36]=[CH:35][C:34]4[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=4)[CH:28]=3)=[CH:25][C:24]([CH2:37][CH2:38][C:39]([OH:41])=[O:40])=[CH:23][C:22]=2[NH:43][CH3:44])[CH2:16][CH2:17][CH2:18][CH2:19]1

Participants

4

Reactant 2

HCID 30179663-(3-Fluoro-4-methoxyphenyl)propionic acidHCID 86614980HCID 86614980, compound

Product 1

HCID 68743427HCID 68743427, compoundYield 24.6%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

According to the procedure described in the synthesis method of Intermediate 9 provided that the reaction was carried out for 6 hours, Intermediate 55 (198 mg) and 2 N aqueous sodium hydroxide (800 μl) were reacted and treated to obtain the title compound (Compound No. S-1, 38 mg).

Workup

  1. customprovided that the reaction
  2. additiontreated

Sources & evidence

ORD record
ord-acd46d0b0a464475a0475bc26581eea3
Source dataset
uspto-grants-2008_12
Patent number
US07470807B2

Reaction notes

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