HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Propynoic acid, 3-cyclopentyl-, ethyl ester → (S)-2-(4-Bicyclo[3.3.1]non-9-yl-phenoxymethyl)-5-cyclopentyl-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Propynoic acid, 3-cyclopentyl-, ethyl ester | HCID 12383859 | — |
| Reactant | (S)-5-(4-bicyclo[3.3.1]non-9-yl-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine | HCID 68527534 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | (S)-2-(4-Bicyclo[3.3.1]non-9-yl-phenoxymethyl)-5-cyclopentyl-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7one | HCID 25069828 | — |
Reaction Steps
The title compound was prepared from (S)-5-(4-bicyclo[3.3.1]non-9-yl-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine (see Example 20) and cyclopentyl-propynoic acid ethyl ester (see Example 102) employing the procedure described in Example 95. [α]D25 −4.80 (c 0.5, CHCl3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642603B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-04a0c205cd034810a1a970f0b9338989 |
| Source note | uspto-grants-2014_02 |