3-(3-Fluoro-4-methoxyphenyl)propionic acid → HCID 22559309, compound

HRID 2378561Notes

Reaction equation

HRID 2378561 reaction equation
FC1C=C(CCC(O)=O)C=C[C:7]=1[O:8]C.Br[C:16]1[S:17][C:18]2[CH:24]=[C:23]([C:25]3[CH:26]=[C:27]([CH2:39][CH2:40][C:41]([O:43]CC)=[O:42])[CH:28]=[CH:29][C:30]=3[O:31][CH2:32][CH:33]3[CH2:38][CH2:37][CH2:36]C[CH2:34]3)[CH:22]=[CH:21][C:19]=2[N:20]=1>[OH-].[Na+]>[CH:33]1([CH2:32][O:31][C:30]2[CH:29]=[CH:28][C:27]([CH2:39][CH2:40][C:41]([OH:43])=[O:42])=[CH:26][C:25]=2[C:23]2[CH:22]=[CH:21][C:19]3[N:20]=[C:16]([O:8][CH3:7])[S:17][C:18]=3[CH:24]=2)[CH2:34][CH2:36][CH2:37][CH2:38]1

Participants

4

Reactant 2

HCID 30179663-(3-Fluoro-4-methoxyphenyl)propionic acidHCID 22558994HCID 22558994, compound

Product 1

HCID 22559309HCID 22559309, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

According to the procedure described in the synthesis method of Intermediate 9 provided that the reaction was carried out for 18 hours, Intermediate 76 (169 mg) and 2 N aqueous sodium hydroxide (500 μl) were reacted and treated to obtain the title compound (Compound No. V-88, 114 mg).

Workup

  1. customprovided that the reaction
  2. additiontreated

Sources & evidence

ORD record
ord-b16f1f0a3f8447528ad3485aeb41f656
Source dataset
uspto-grants-2008_12
Patent number
US07470807B2

Reaction notes

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