HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxybenzaldehyde → HCID 68745335, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxybenzaldehyde | HCID 126 | — |
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | 3-(3-Bromo-4-hydroxyphenyl)prop-2-enoic acid | HCID 20986537 | — |
| Reactant | HCID 22559225 | HCID 22559225 | — |
| Product | HCID 68745335 | HCID 68745335 | — |
Reaction Steps
According to the procedure described in the synthesis method of Intermediate 43, 3-[3-bromo-4-hydroxylphenyl]acrylic acid (12.01 g) obtainable from 4-hydroxybenzaldehyde (TCI) by a method known from literature (Y. Nagao et al., Tetrahedron Lett., 1980, p. 4931) was reacted with imidazole (16.01 g) and t-butyldimethylsilyl chloride (7.43 g) and treated to obtain the title compound (Intermediate Ac-1, 17.43 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07470807B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-2de06a2b2dc7440da1c3ee0ccfe2f0e7 |
| Source note | uspto-grants-2008_12 |