HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-butynoate → (S)-5-Methyl-2-[4-(1,1,3,3-tetramethyl-butyl)-phenoxymethyl]-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-butynoate | HCID 78043 | — |
| Reactant | (S)-5-(4-(1,1,3,3-tetramethyl-butyl)-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine | HCID 68529278 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | (S)-5-Methyl-2-[4-(1,1,3,3-tetramethyl-butyl)-phenoxymethyl]-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one | HCID 25069829 | — |
Reaction Steps
The title compound was prepared from (S)-5-(4-(1,1,3,3-tetramethyl-butyl) -phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine (see Example 27) and but-2-ynoic acid ethyl ester employing the procedure described in Example 95. [α]D25 −36.20 (c 0.5, CHCl3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642603B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-901311deb423465795af29c068f23ef1 |
| Source note | uspto-grants-2014_02 |