HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Ethoxy-but-2-ynoic acid methyl ester → (S)-2-(4-Cyclohexyl-phenoxymethyl)-5-ethoxymethyl-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Ethoxy-but-2-ynoic acid methyl ester | HCID 64535168 | — |
| Reactant | (S)-5-(4-cyclohexyl-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine | HCID 66875140 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | (S)-2-(4-Cyclohexyl-phenoxymethyl)-5-ethoxymethyl-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one | HCID 59252492 | — |
Reaction Steps
The title compound was prepared from (S)-5-(4-cyclohexyl-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine and 4-ethoxy-but-2-ynoic acid methyl ester employing the procedure described in Example 94. [α]D25 −9.80 (c 0.5, CHCl3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642603B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-b573336d1a924fdbb53c3555949847cf |
| Source note | uspto-grants-2014_02 |