反应详情

温度

160 °C

To a solution of (S)-5-(4-bicyclo[3.3.1]non-9-yl-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine (0.600 g, 1.91 mmol) in ethanol (5 mL) was added 0.294 g (2.86 mmol) of 5-methyl-hex-2-ynoic acid ethyl ester. The reaction mixture was heated in a microwave oven at 160° C. for 20 minutes. The reaction mixture was concentrated and purified by chromatography on silica gel eluting with MeOH/CH2Cl2 to afford 0.283 g of the title compound. [α]D25 −11.17 (c 0.537, CHCl3).

1. concentrationThe reaction mixture was concentrated
2. custompurified by chromatography on silica gel eluting with MeOH/CH2Cl2