Hydrochloric Acid → HCID 67090453, compound

Participants

Reaction Steps

Compound 49 (1.0 g, 2.80 mmol) was dissolved in ethanol (40 mL), then the solution was added with 2 mol/L aqueous sodium hydroxide solution (15.0 mL) at 0° C., and was warmed to room temperature. After stirring for 6 hours, the reaction mixture was neutralized with 2 mol/L hydrochloric acid and was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and was concentrated. The residue was recrystallized from ethyl acetate and methanol to obtain Compound 50 (654 mg, 70%).

Provenance & Evidence