Hydrochloride methanol → HCID 67089732, compound

HRID 2378730Notes

Reaction equation

HRID 2378730 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15](=[O:33])[C:16]2[CH:21]=[CH:20][C:19](/[CH:22]=[CH:23]/[C:24]3[C:32]4[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=4)[NH:26][N:25]=3)=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:34].CO>CO>[ClH:34].[ClH:34].[NH:26]1[C:27]2[C:32](=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:24](/[CH:23]=[CH:22]/[C:19]2[CH:18]=[CH:17][C:16]([C:15]([N:11]3[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]3)=[O:33])=[CH:21][CH:20]=2)=[N:25]1

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 67090112HCID 67090112, compound

Product 1

HCID 67089732HCID 67089732, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

A solution of Compound 82 (100 mg, 0.224 mmol) in methanol (10.0 mL) was added with 10% hydrogen chloride-methanol solution (10.0 mL), followed by stirring at 60° C. for 2 hours. After cooling to room temperature, deposited crystal was collected by filtration to obtain Compound 85 (48.7 mg, 47%).

Workup

  1. temperatureAfter cooling to room temperature
  2. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-e84a00cd31af49098726d87836df920b
Source dataset
uspto-grants-2008_12
Patent number
US07470717B2

Reaction notes

Loading…