Hydrochloride methanol → HCID 67089898, compound

HRID 2378733Notes

Reaction equation

CC(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:33])[C:15]2[CH:20]=[CH:19][C:18](/[CH:21]=[CH:22]/[C:23]3[C:31]4[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=4)[NH:25][N:24]=3)=[CH:17][C:16]=2[CH3:32])[CH2:10][CH2:9]1)=O)(C)C.[ClH:34].CO>>[ClH:34].[ClH:34].[NH:25]1[C:26]2[C:31](=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:23](/[CH:22]=[CH:21]/[C:18]2[CH:19]=[CH:20][C:15]([C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[O:33])=[C:16]([CH3:32])[CH:17]=2)=[N:24]1

Participants

Reactant 2

HCID 21893726Hydrochloride methanol

HCID 67089667HCID 67089667, compound

Product 1

HCID 67089898HCID 67089898, compoundYield 77%

Procedure

(E)-4-{4-[2-(1H-indazol-3-yl)vinyl]-2-methylbenzoyl}piperazine-1-carboxylic acid 1,1-dimethylethyl ester (980 mg, 2.20 mmol) obtained in Step 1, was treated with 10% hydrogen chloride-methanol solution to obtain Compound 95 (585 mg, 77%).

Sources & evidence

ORD record: ord-4e6763d0ce2f486f91914e6370794d3e
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07470717B2

Reaction notes

Loading…