HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → (E)-1-{4-[2-(1H-indazol-3-yl)vinyl]benzoyl}-4-(morpholinocarbonylamino)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Morpholinecarbonyl chloride | HCID 84810 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | (E)-1-{4-[2-(1H-indazol-3-yl)vinyl]benzoyl}-4-aminopiperidine | HCID 11221716 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (E)-1-{4-[2-(1H-indazol-3-yl)vinyl]benzoyl}-4-(morpholinocarbonylamino)piperidine | HCID 67089582 | 0.3% |
Reaction Steps
Compound 64 (500 mg, 1.19 mmol) was dissolved in dichloromethane, and the solution was added with triethylamine (0.498 mL, 3.57 mmol), 4-morpholinecarbonyl chloride (468 mg, 2.62 mmol) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (200.2 mg, 1.04 mmol) at 0° C., followed by stirring for 4 hours to obtain Compound 99 (1.5 mg, 0.3%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07470717B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-0209c8e8c99d48c9891d1c160f1ea6f7 |
| Source note | uspto-grants-2008_12 |