HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 67089612, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 1-((Pyrrolidine-1-carbonyl)methyl)piperazine | HCID 100614 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| Reactant | (E)-4-(2-(1H-indazol-3-yl)vinyl)benzoic acid | HCID 11437002 | — |
| Product | HCID 67089612 | HCID 67089612 | 60% |
Reaction Steps
The crude product obtained using (E)-4-[2-(1H-indazol-3-yl)vinyl]benzoic acid (300 mg, 1.14 mmol) obtained in Step 6 of Example 1, N-methylmorpholine (0.25 mL, 2.28 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (305 mg, 1.59 mmol), 1-hydroxybenzotriazole monohydrate (200 mg, 1.48 mmol) and 2-(piperazin-1-yl)-1-(pyrrolidin-1-yl)ethanone (337 mg, 1.71 mmol) in a similar manner to Step 7 of example 1, was triturated in mixed solvent of ethyl acetate/methanol to obtain Compound 121 (298 mg, 60%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07470717B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-43bf09a71b844ff3903d17e1f3ce8d46 |
| Source note | uspto-grants-2008_12 |