Sodium Carbonate → HCID 59252507, compound

Participants

Reaction Steps

To a solution of 2-(4-cyclohexyl-phenoxymethyl)-5-ethylsulfanylmethyl-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one (0.3 g, 0.75 mmol) in HOAc (20 mL) was added sodium perborate tetrahydrate (0.3 g, 1.95 mmol). The reaction mixture was stirred at room temperature overnight. The reaction mixture was neutralized with sodium hydroxide (2N) to pH˜7 and further to pH˜10 with aqueous sodium carbonate. The mixture was extracted with EtOAc three times. The organic phase was washed with brine and dried (Na2SO4). Silica gel chromatography (MeOH/CH2Cl2) provided 0.254 g of the title compound. [α]D25 +5.45 (c 0.5, CHCl3).

Provenance & Evidence