Ethyl propiolate → HCID 59252502, compound

Participants

Reaction Steps

To a stirred solution of 5-[2-(4-cyclohexyl-phenyl)-ethyl]-4,5-dihydro-oxazol-2-ylamine (0.134 g, 0.493 mmol) in 5 ml of ethanol was added 50 μL (0.494 mmol) of ethyl propiolate. The mixture was stirred at 80° C. for 6h and allowed to cool to room temperature. The mixture was concentrated to a solid which was purified by chromatography on silica gel eluting with ethyl acetate followed by methanol/ammonia/dichloromethane to provide 70 mg of the title compound.

Provenance & Evidence