Trimethylsilyl iodide → HCID 59006343, compound

Participants

Reaction Conditions

Reaction Steps

To tert-butyl 4-(5-methoxy-1-methyl-1H-pyrrolo [3,2-b]pyridin-6-yl)piperidine-1-carboxylate (104 mg, 0.301 mmol) in CH2Cl2 (3 mL) was added TMS-I (123 μl, 0.903 mmol) at rt. The resulting brown solution was stirred at 60° C. over night. Partial of the solvent was removed on rotary vacuo, the residue was purified on reverse phase PrepHPLC to afford the expected product, 1-methyl-6-(piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5(4H)-one (65 mg, 94%). 1H-NMR (400 MHz, MeOD) δ ppm 2.05 (s, 3 H) 2.13 (s, 3 H) 3.20 (s, 4 H) 3.55 (s, 3 H) 6.25 (s, 1 H) 7.35 (s, 1 H) 8.01 (s, 1 H); Mass spec 232.19 Calc for C13H17N3O 231.14.

Provenance & Evidence