Methanol → HCID 54319561, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3 g of (S)-2-(4-[methoxycarbonyl]phenyl)-4-isopropyl-2-oxazoline, 3 g of potassium hydroxide, 5 ml of water and 50 ml of methanol is heated at 75° C. on an oil bath for 4 hours. The cooled mixture is treated with 10 ml of ice-cold 3N hydrochloric acid and the liberated acid is taken up in 150 ml of diethyl ether. The separated aqueous phase is back-extracted twice with 100 ml of diethyl ether each time. The combined organic phases are washed with 50 ml of 2N sodium carbonate solution and several times with water, dried over magnesium sulphate and concentrated. Recrystallization of the resulting crude product from ethanol yields (S)-2-(4-carboxyphenyl)-4-isopropyl-2-oxazoline.

Provenance & Evidence