Pyridine → HCID 67828555, compound

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Reaction Steps

To a 10 ml round bottomed flask fitted with a magnetic stirrer bar, reflux condensor, and nitrogen inlet was added 1,6-dihydro-1-[2-(3-pyridinylcarbonylamino)ethyl]-6-oxo-3-pyridinecarboxylicacid (0.14 g, 0.49 mmol) and thionyl chloride (3.0 ml). The mixture was heated for 1 hour at reflux, cooled to room temperature, and concentrated. The residue was suspended in absolute ethanol (7.0 ml) and 4-dimethylaminopyridine (1 mg). Pyridine (0.12 ml, 1.47 mmol) was added with stirring at room temperature. After 16 hours, the mixture was concentrated. Purification via medium liquid chromotography (silica gel, 5-10% methanol/dichloromethane) gave the desired ester, MP: 240°-242° C.

Provenance & Evidence