HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-2-methoxybenzoyl chloride → 1-[2-(5-Chloro-2-methoxybenzoylamino)ethyl]-1,6-dihydro-6-oxo-3-pyridinecarboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-2-methoxybenzoyl chloride | HCID 12384176 | — |
| Reactant | Methyl 1-(2-aminoethyl)-6-oxo-1,6-dihydropyridine-3-carboxylate | HCID 54083902 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-[2-(5-Chloro-2-methoxybenzoylamino)ethyl]-1,6-dihydro-6-oxo-3-pyridinecarboxylic acid methyl ester | HCID 53691442 | — |
Reaction Steps
1-(2-aminoethyl)-1,6-dihydro-6-oxo-3-pyridinecarboxylic acid methyl ester (0.985 g, 5.0 mmol) was reacted with 5-chloro-2-methoxybenzoyl chloride (1.04 g, 5.1 mmol) in dichloromethane (25 ml) and pyridine (10 ml). After an aqueous work-up, purification via flash column chromotography (silica gel, 8% methanol/dichloromethane) gave the product, MP: 149°-150° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05360808 |
| Source dataset | uspto-grants-1994_11 |
| ORD ID | ord-9df25bd9a8ef496db3ea87da5b5d647f |
| Source note | uspto-grants-1994_11 |