HCID 136378422, compound → HCID 18957950, compound

Participants

Reaction Steps

A solution of 13.0 g (38 mmol) of potassium hexacyanoferrate(III) in 40 ml of water and 3 ml of saturated sodium carbonate solution is added dropwise to a suspension of 1.0 g (6.4 mmol) of 1-methyl-2,3,4-pyrrolidinetrione-3,4-dioxime in 50 ml of ethyl acetate, and the mixture is stirred at room temperature for 2 hours. The organic phase is separated off and concentrated, and the residue is purified by flash chromatography (ethyl acetate/cyclohexane 60:40). 0.34 g (34%) of 5,6-dihydro-5-methyl-4H-pyrrolo[3,4-c][1,2,5]oxadiazole-4-one-1-oxide and -3-oxide is obtained in the ratio 1:2 (NMR), m.p. 49°-52° C.

Provenance & Evidence