4-Chlorobenzenesulfonyl chloride → HCID 15724015, compound

HRID 2379111Notes

Reaction equation

HRID 2379111 reaction equation
[NH2:1][C@H:2]([CH3:19])[C@:3]([C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=1[Cl:18])([OH:10])[CH2:4][N:5]1[CH:9]=[N:8][CH:7]=[N:6]1.[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([S:27](Cl)(=[O:29])=[O:28])=[CH:23][CH:22]=1>>[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([S:27]([NH:1][C@H:2]([CH3:19])[C@:3]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=2[Cl:18])([OH:10])[CH2:4][N:5]2[CH:9]=[N:8][CH:7]=[N:6]2)(=[O:29])=[O:28])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 73984-Chlorobenzenesulfonyl chlorideHCID 14706470HCID 14706470, compound

Product 1

HCID 15724015HCID 15724015, compound

Procedure

Following the general sulfonylation procedure explained in example 1 and using (2R*,3R*)-3-amino-2-(2,4-dichlorophenyl)-l-(1H-1,2,4-triazol-1-yl)butan-2-ol, prepared as described in EP 332,387, and 4-chlorobenzenesulfonyl chloride, the title product is obtained in similar yield.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-b98dee96f3044a048102bd4e643bc2dd
Source dataset
uspto-grants-1994_11
Patent number
US05360813

Reaction notes

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