HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-(Benzyloxycarbonyl)-4,6-dibromotryptophan ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzyl chloroformate | HCID 10387 | — |
| Reactant | 4,6-Dibromotryptophan ethyl ester | HCID 18656067 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(Benzyloxycarbonyl)-4,6-dibromotryptophan ethyl ester | HCID 53945469 | — |
Reaction Steps
Mix DL-4,6-dibromotryptophan ethyl ester (1.20g, 3.07mmol), triethylamine (341mg, 3.38mmol)and methylene chloride (50mL). Add benzyl chloroformate (692mg, 4.06mmol) and stir for 12 hours. Dilute with methylene chloride, wash with 1M hydrochloric acid (100mL) and brine (100mL). Dry (MgSO4) and evaporate the solvent in vacuo and purify by silica gel chromatography to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05360814 |
| Source dataset | uspto-grants-1994_11 |
| ORD ID | ord-a024dcab52fc4279a4cbfe105bd69594 |
| Source note | uspto-grants-1994_11 |