Ammonium Chloride → HCID 18957882, compound

Participants

Reaction Steps

To a solution of 1-(3-biphenylyl)-5-isopropoxycarbonylbenzimidazole (0.52 g, 1.6 mmol) in dry toluene (5 ml) under nitrogen at a temperature of -70° C. was added diisobutylaluminum hydride (1.1 ml of an 1.5M solution in toluene). After 1.5 h at -70° the reaction mixture was allowed to reach room temperature and was then poured in a slurry of 2M aqueous ammonium chloride and ice. After extractive workup with toluene the product was purified by chromatography on silica gel. Yield: 60 mg, 0.2 mmol, 12%. mp 130°-131° C.

Provenance & Evidence