Thionyl Chloride → HCID 15616313, compound

Participants

Reaction Steps

A solution of thionyl chloride (0.12 ml) in dry dichloromethane (1.2 ml) was added dropwise to a cold (0°) stirred solution of 4-(hydroxymethyl)-N,N-dimethyl-5-propyl-1H-imidazole-1-sulphonamide (340 mg) in dry dichloromethane (7.5 ml) under nitrogen. After 1.5 h the solution was washed with 8% sodium bicarbonate solution (2×15 ml) and the aqueous phase was extracted with dichloromethane (2×10 ml). The combined organic extracts were washed with water (15 ml), dried and evaporated to give the title compound (180 ml) as an oil, t.l.c. (ethyl acetate) Rf 0.68.

Provenance & Evidence