HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 2,3,4,5-Tetrahydro-5-(phenylmethyl)-1H-pyrido[4,3-b]indol-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indol-1-one | HCID 15616323 | — |
| Product | 2,3,4,5-Tetrahydro-5-(phenylmethyl)-1H-pyrido[4,3-b]indol-1-one | HCID 15616326 | 41.9% |
Reaction Steps
2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indol-1-one (559 mg) was treated with sodium hydride (73% dispersion in oil; 197 mg) and was then stirred with benzyl bromide (513 mg) at room temperature for 30 min. Purification by FCC eluting with dichloromethan: ethanol (80:1) gave the title compound (347 mg), m.p. 209°-212°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05360800 |
| Source dataset | uspto-grants-1994_11 |
| ORD ID | ord-7c6403773c704754961575faf751256c |
| Source note | uspto-grants-1994_11 |