1H-Pyrido(4,3-b)indol-1-one, 2,3,4,5-tetrahydro-5-methyl- → HCID 15616332, compound

HRID 2379143Notes

Reaction equation

HRID 2379143 reaction equation
[CH3:1][N:2]1[C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[C:4]2[C:11](=[O:15])[NH:12][CH2:13][CH2:14][C:3]1=2>[Pd]=O>[CH3:1][N:2]1[C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[C:4]2[C:11](=[O:15])[NH:12][CH:13]=[CH:14][C:3]1=2

Participants

3

Reactant 1

HCID 117902131H-Pyrido(4,3-b)indol-1-one, 2,3,4,5-tetrahydro-5-methyl-

Product 1

HCID 15616332HCID 15616332, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 5083724Palladium monoxideCatalyst

Procedure

A mixture of 2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one (500 mg) and 10% palladium oxide on carbon catalyst (50% aqueous paste; 250 mg) was heated at 320° for 10 min. The cooled solid was triturated with ethanol (ca. 100 ml), filtered and the resulting filtrate was evaporated to give the title compound (470 mg), m.p. 242.5°.

Workup

  1. temperaturewas heated at 320° for 10 min
  2. customThe cooled solid was triturated with ethanol (ca. 100 ml)
  3. filtrationfiltered
  4. customthe resulting filtrate was evaporated

Sources & evidence

ORD record
ord-013cf0131b484aa3b31c739b36608381
Source dataset
uspto-grants-1994_11
Patent number
US05360800

Reaction notes

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