Hydrochloric Acid → 2,4-Dioxo-1-[(5-methyl-1H-imidazol-4-yl)methyl]piperidine

Participants

Reaction Steps

To a solution of 5,6-dihydro-4-methoxy-1-[[5-methyl-1-(triphenylmethyl)-1H-imidazol-4yl]methyl]-2(1H)-pyridinone (500 mg) in THF (4 ml) was added hydrochloric acid (5M; 1 ml), and the mixture was stirred at 50° for 1 h. The solvent was removed in vacuo, triethylamine (1 ml) was added, and the mixture was again evaporated to dryness. FCC of the residue eluting with ethyl acetate:methanol:triethylamine (8:4:1) gave the title compound (139 mg), m.p. 100°-106° (decomp.).

Provenance & Evidence