Methane → HCID 15616303, compound

Participants

Reaction Steps

2,3,4,5-Tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one (0.81 g) was suspended in absolute ethanol (6 ml) and was warmed at 50° with concentrated sulphuric acid (0.15 ml). More ethanol (4 ml) was added and the mixture was stirred with charcoal (0.1 g). The suspension was then filtered and the collected solid was washed with ethanol (ca. 3 ml). The resulting filtrate was stirred for ca. 1 h at room temperature, tert-butyl methyl ether (10 ml) was added slowly and the mixture was stirred for 20 min. The precipitate was filtered off, washed with ethanol:tert-butyl methyl ether (1:1;6 ml), then with tert-butyl methyl ether (6 ml), and dried in vacuo at 40° for 4 days to give the title compound (0.4 g), m.p. 205°-209°.

Provenance & Evidence