HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Tetrachloride → 7-Chloromethyl-4-(3-thienyl)coumarin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Tetrachloride | HCID 5943 | — |
| Reactant | Hexamethylphosphorous triamide | HCID 15355 | — |
| Reactant | 7-Hydroxymethyl-4-(3-thienyl)coumarin | HCID 15780558 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 7-Chloromethyl-4-(3-thienyl)coumarin | HCID 15780559 | — |
Reaction Steps
To a solution of the alcohol from Step 1 (1.65 g) and hexamethylphosphorous triamide in 35 mL THF at 0° C. was added CCl4 (1.3 mL) and the mixture stirred for 30 min. The mixture was diluted with Et2O, filtered, concentrated and the residue chromatographed (30% EtOAc/hexane) to provide the title compound as a solid, m.p. 125°-127° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05360815 |
| Source dataset | uspto-grants-1994_11 |
| ORD ID | ord-4828045f914c4333a1b7673ed910096b |
| Source note | uspto-grants-1994_11 |