HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Garomefrine Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 86748228 | HCID 86748228 | — |
| Product | Garomefrine Hydrochloride | HCID 9838762 | — |
Reaction Steps
(R)-(-)-3'-(2-Amino-1-hydroxyethyl)-4'-fluoromethanesulfonanilide L-(+)-tartrate (2.0 g) was made into a free base using ion exchange resin (Dowex 50W X2) followed by treating with 20% ethanolic hydrochloric acid. The crystals which were separated out were collected to give 1.1 g of (R)-(-)-3'-(2-amino-1-hydroxyethyl)-4'-fluoromethanesulfonanilide hydrochloride, m.p. 189°-191° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05360822 |
| Source dataset | uspto-grants-1994_11 |
| ORD ID | ord-c6e8fd5788f543059b628e5dd7039b3c |
| Source note | uspto-grants-1994_11 |