Sodium borohydride → HCID 15232561, compound

Participants

Reaction Steps

3'-(2-Aminoacetyl)-5'-fluoromethanesulfonanilide hydrochloride (1.7 g) was suspended in 70 ml of methanol, then 114 mg of sodium borohydride was added thereto with stirring at 5°-10° C. and the mixture was stirred at room temperature for 30 minutes. The solvent was evaporated and the residue was made into a free base using ion exchange resin (Dowex 50W X2) followed by recrystallizing from methanol-ethanol to give 1.07 g of (±)-3'-(2-amino-1-hydroxyethyl)-5'-fluoromethanesulfonanilide, m.p. 167°-169° C.

Provenance & Evidence