Benzene → HCID 18958045, compound

Participants

Reaction Steps

The preceding amino-ketone (1.03 g, 10 mmol) was dissolved in dry benzene (20 mL). Triethylamine (1.5 mL) was added. Pentafluorobenzoyl chloride (2.31 g, 10 mmol) was added dropwise with stirring over 10 min. The reaction mixture was stirred at room temperature for 30 min, and then acidified with 10% HCl. Ethyl acetate was added, and the organic layer washed with 10% NaHCO3, H2O, and dried over anhydrous Na2SO4. Evaporation of the solvent afforded a yellow oil which was purified by flash column chromatography (3:7 ethyl acetate/hexane) to give white crystals (1.65 g, 55%),

Provenance & Evidence