HCID 18958289, compound → HCID 136378424, compound

Participants

Reaction Conditions

Reaction Steps

N-(3-bromo-5-isoxazolylmethyl)ethylene diamine (4 g), prepared as described above, and nitroguanidine (2.5 g), were added to water (50 ml) and the reaction mixture stirred at 80° C. for 1 hour. The reaction mixture was partitioned with trichloromethane and the organic layer was separated, washed and dried. Thin layer chromatography showed a single product and was used to recover the product as a colorless solid (2.1 g). Recrystallization gave the title compound as colorless crystals (m.p. 149° C.).

Provenance & Evidence