HCID 11011939, compound → HCID 10946429, compound

Participants

Reaction Steps

A solution of 0.2 g of (E)-2-acetyl-1,2,3,4,5,6,7,8-octahydro-1-(p-methoxybenzylidene)isoquinoline and 8.7 mg of dichlorobis(acetonitrile)palladium(II) in 10 ml of dry tetrahydrofuran was heated at reflux for 7 hours under argon. The yellow solution was evaporated at 15 mbar and the residue was dissolved in diethyl ether. In order to separate the catalyst, the ether solution was filtered through a thin layer of silica gel. After evaporation of the filtrate there was obtained 0.19 g of (Z)-2-acetyl-1,2,3,4,5,6,7,8-octahydro-1-(p-methoxybenzylidene)-isoquinoline with a m.p. of 101-102° C.; content according to GC 96%:

Provenance & Evidence