HCID 11011939, compound → HCID 18958303, compound

Participants

Reaction Steps

A solution of 2.1 g of (E)-2-acetyl-1,2,S,4,5,6,7,8-octahydro-1-(p-methoxybenzylidene)isoquinoline (prepared according to Example 1) in 120 ml of methylene chloride was heated at reflux for 2 hours under argon. The solvent was then distilled off at 30° C./20 mbar. The residue, 2.3 g of a colorless oil, contained 61% of the desired product according to GC. Column chromatography and crystallization from isopropyl ether gave 700 mg of 2-acetyl-1 -(p-methoxybenzyl)-2,3,4,6,7,8-hexahydroisoquinoline, which was pure according to thin-layer chromatography and gas chromatography, as white crystals. M.p. 48°-50° C.

Provenance & Evidence