Pyridine → HCID 9965205, compound

HRID 2379309Notes

Reaction equation

HRID 2379309 reaction equation
[NH:1]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[C@H:2]([C:10](O)=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[F-:20].N1C=CC=CC=1>C(Cl)Cl>[NH:1]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[C@H:2]([C:10]([F:20])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 28179Fluoride IonHCID 77857L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-

Product 1

HCID 9965205HCID 9965205, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

BOC-Phe (1 mmole) in dry CH2Cl2 under nitrogen is treated with cyannuric fluoride (8 mmol) and pyridine (1 mmole) to form the above-identified product.

Workup

  1. customto form the above-identified product

Sources & evidence

ORD record
ord-e1bd09eff20a454f87dfb4baa2b24542
Source dataset
uspto-grants-1994_11
Patent number
US05360928

Reaction notes

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