Triethylamine → HCID 131718766, compound

Participants

Reaction Steps

The title compound was prepared in the same way as that described in Example 11, Step 4, using 5-cyclohexyl-l,3-dihydro-1-methyl-3(R,S)-[(4-nitrophenyloxycarbonyl)amino ]-2H-1,4-benzodiazepin-2-one (0.5 g, 1.2 mmol), triethylamine (0.16 ml, 1.2 mmol), dimethylformamide (10 ml) and 1-(methylcarbonylaminosulphonyl)-3-aminobenzene (0.26 g, 1.2 mmol).After recrystallisation from methanol, the title compound (0.2 g, 34%) was afforded as a colourless solid. mp 195°-198° C. 1H NMR (360 MHz, D6 -DMSO) δ 0.87-0.99 (1H, m), 1.10-1.66 (7H, m), 1.78 (1H, m), 1.94 (1H, m), 1.91 (3H, s), 2.95 (1H, m), 3.30 (3H, s), 5.07 (1H, d, J=8.3 Hz), 7.39 (4H, m), 7.54 (2H, m), 7.64 (1H, dd, J=7.9 and 7.9 Hz), 7.76 (1H, d, J=7.9 Hz), 8.07 (1H, s), 9.42 (1H, s), 11.99 (1H, brs).

Provenance & Evidence