HCID 18957764, compound → HCID 18957761, compound

Participants

Reaction Steps

A solution of 1-(1,1-dimethylethyloxycarbonyl)-2-((3-nitrophenyl)ethen-2-yl)imidazole (500 mg, 1.59 mmol)in ethanol (50 ml) was hydrogenated at 30 psi in the presence of 10% palladium-on-carbon (50 mg) for 1 h. The catalyst was then removed by filtration and the solvent evaporated to afford the titled compound as a viscous oil (340 mg, 75% yield). 1H NMR (250 MHz, CDCl3) δ 1.60 (9H, s), 2.92-3.04 (2H, m), 3.22-3.36 (2H, m), 3.70 (2H, brs), 6.42-6.68 (3H, m), 6.87 (1H, d, J =2.5 Hz), 7.05 (1H, t, J=8 Hz), 7.32 (1H, d, J=2.5 Hz).

Provenance & Evidence