Water → Butanedioic acid, 2-[(carboxymethyl)thio]-

HRID 2379380Notes

Reaction equation

[OH2:1].[C:2]1(=[O:8])[O:7][C:5](=[O:6])[CH:4]=[CH:3]1.[C:9]([OH:13])(=[O:12])[CH2:10][SH:11]>>[C:9]([CH2:10][S:11][CH:3]([CH2:4][C:5]([OH:1])=[O:6])[C:2]([OH:7])=[O:8])([OH:13])=[O:12]

Participants

Reactant 3

HCID 962Water

HCID 1133Thioglycolic Acid

HCID 7923Maleic Anhydride

Product 1

HCID 97922Butanedioic acid, 2-[(carboxymethyl)thio]-

Conditions

Temperature: 90 °C

Procedure

A solution of 180 g (10 mol) of water and 98 g (1.0 mol) of maleic anhydride was heated to 40° C. To this solution was added 92 g (1.0 mol) of thioglycolic acid and the reaction mixture was heated to 90° C. with stirring. After three (3) hours at 90° C., the water was evaporated off under reduced pressure. The resulting molten product was cast and ground prior to use.

Workup

customAfter three (3) hours at 90° C., the water was evaporated off under reduced pressure

Sources & evidence

ORD record: ord-913db5c352dd435db6f81e96169497e0
Source dataset: uspto-grants-1994_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05362412

Reaction notes

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