HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiazolidinedione → 5-[(3,4-Dihydroxy-5-chlorophenyl)methylidene]-thiazolidin-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiazolidinedione | HCID 5437 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 3-Chloro-4,5-dihydroxybenzaldehyde | HCID 2468182 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-[(3,4-Dihydroxy-5-chlorophenyl)methylidene]-thiazolidin-2,4-dione | HCID 54030399 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A solution containing 1.33 g of thiazolidine-2,4-dione, 1.72 g of 3,4-dihydroxy-5-chlorobenzaldehyde and 2 ml of piperidine in 20 ml of acetic acid was heated for five hours at 100 ° C. Yield 1.9 g (70%), mp 299°-301° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05362733 |
| Source dataset | uspto-grants-1994_11 |
| ORD ID | ord-9280142cdc7148eea86c11a532dbd818 |
| Source note | uspto-grants-1994_11 |