Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2-Dichlorobenzene → 1-Fluoro-2-nitronaphthalene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2-Dichlorobenzene | HCID 7239 | — |
| 반응물 | 2-Nitronaphthalen-1-amine | HCID 136403 | — |
| 반응물 | Nitrilooxonium tetrafluoroborate | HCID 11137142 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-Fluoro-2-nitronaphthalene | HCID 22008471 | — |
반응 단계
To a well stirred slurry of nitrosonium tetrafluoroborate (Aldrich) (10 % molar excess, (cf. David J. Milner, Synthetic Communications (1992) 22 (1), 73-82.)) in dichloromethane at 0° C. is added 1-amino-2-nitronaphthalene. After 30 minutes, ortho-dichlorobenzene is added and the dichloromethane is distilled off, and the dichlorobenzene is heated at 50°-200 ° C. to decompose the diazonium tetrafluoroborate. Removal of solvent and purification of the product by chromatography or crystallization yields 1-fluoro-2-nitronaphthalene.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05362747 |
| 출처 데이터셋 | uspto-grants-1994_11 |
| ORD ID | ord-d9497c760e6047559109574ac42038e4 |
| 출처 메모 | uspto-grants-1994_11 |