Hydrochloric Acid → HCID 178420489, compound

Participants

Reaction Steps

A suspension of 1-phenyl-1H-tetrazol-5-amine (38.63 g, 0.2397 mol) in xylenes (380 mL) was refluxed under nitrogen for 1.3 hours and allowed to cool. The suspension was stirred overnight. The mixture was chilled (+3° C.) for 2 hours, and the solids were filtered off. The filter cake was washed with PET ether and then dissolved in a solution of potassium hydroxide (20.1 g, 0.358 mol) in water (1.1 L). The mixture was filtered, and the filtrate was acidified by the dropwise addition of concentrated hydrochloric acid (46 mL, 0.55 mol). A precipitate formed. The solids were filtered off, washed with water (25 mL), and dried under house vacuum/air stream (40° C.), yield 35.0 g h(90%); mp=208°-209° C. (gas evol.)

Provenance & Evidence