Water → HCID 21804318, compound

Participants

Reaction Steps

136 g (0.531 mol) of 2-hydroxy-2-(3-benzyl-phenyl)-propanoic acid (product from Example 11) are refluxed in a mixture of 3 l of dioxane and 180 ml of concentrated sulphuric acid. Water is added to the mixture which has been concentrated to approximately 500 ml and the mixture is extracted three times with ether. After drying the organic phases using saturated NaCl and magnesium sulphate, a brown oil remains, which is purified by filtration on 1 kg of silica gel (ethyl acetate/cyclohexane 5:1). Yield: 83 g (66%).

Provenance & Evidence