HCID 21804317, compound → HCID 21804319, compound

Participants

Reaction Steps

A mixture of 2.40 g (8.96 mmol) of methyl 2-(3-(hydroxy-phenyl-methyl)-phenyl)-propenoate (product from Example 15a) in 1.76 g of lithium hydroxide, 16 ml of water, 18 ml of acetonitrile and 18 ml of heptane is treated overnight with intensive stirring using a mechanic stirrer. The acetonitrile/water phase is then separated and concentrated. The resulting residue is taken up in ethyl acetate and extracted with sodium hydroxide solution. The basic extract is acidified using hydrochloric acid and extracted with ethyl acetate, dried and concentrated. Yield: 1.87 g (7.36 mmol) (82.1% of theory)

Provenance & Evidence