Lithium hydroxide, monohydrate → HCID 18957360, compound

Participants

Reaction Steps

A mixture of methyl [3-[N-acetyl-[(4,5-diphenyl-2-oxazolyl)methyl]amino]phenoxy]acetate (0.58 g, 1.3 mmol), LiOH.H2O (0.05 g, 1.3 mmol) and MeOH (30 mL) was stirred at room temperature for about 15 hours before adding LiOH.H2O (0.05 g, 1.3 mmol). After about 1 hour, the solvent was evaporated, the residue diluted with 1N HC1 solution and extracted with CH2Cl2. The combined extracts were washed with saturated NaCl solution, dried over MgSO4 and concentrated in vacuo to leave [3-[N-acetyl-[(4,5-diphenyl-2-oxazolyl) methyl]amino]phenoxy]acetic acid (0.51 g, 91%), mp 75-80° C. IR (KBr) 2500 (CO2H), 1740 (CO2H), 1660 (NCOCH3) cm-1 ; 1H NMR (CDCl3) δ1.95 (3H, s, COCH3), 4.55 (2H, s, OCH2), 5.11 (2H, s, NCH2) 6.70-6.95 (3H, m, aromatic H) , 7.25-7.40 (7H, m, aromatic H) , 7.45-7.65 (4H, m, aromatic H); MS m/z 443 (MH+).

Provenance & Evidence