5-Aminoisoquinoline → N-(Isoquinolin-5-yl)-2-(decyl)cyclopentane carboxamide

HRID 2379606Notes

Reaction equation

[CH2:1]([CH:11]1[CH2:15][CH2:14][CH2:13][CH:12]1[C:16]([OH:18])=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[NH2:19][C:20]1[CH:29]=[CH:28][CH:27]=[C:26]2[C:21]=1[CH:22]=[CH:23][N:24]=[CH:25]2>>[CH:25]1[C:26]2[C:21](=[C:20]([NH:19][C:16]([CH:12]3[CH2:13][CH2:14][CH2:15][CH:11]3[CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])=[O:18])[CH:29]=[CH:28][CH:27]=2)[CH:22]=[CH:23][N:24]=1

Participants

Reactant 2

HCID 707665-Aminoisoquinoline

HCID 149954162-(Decyl)cyclopentane carboxylic acid

Product 1

HCID 19027797N-(Isoquinolin-5-yl)-2-(decyl)cyclopentane carboxamide

Procedure

2-(Decyl)cyclopentane carboxylic acid, prepared according to the procedure of Hoefle, et. al. (U.S. Pat. No. 4,715,175), was coupled with 5-aminoisoquinoline according to the procedure outlined in Example 47 to give the title compound.

Sources & evidence

ORD record: ord-e81873c687bd4adab9c410c2f89ee9f5
Source dataset: uspto-grants-1994_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05362878

Reaction notes

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