HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 2-Methoxy-4-methylpyridin-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 2-Hydroxy-4-methyl-3-nitropyridine | HCID 345370 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-Methoxy-4-methylpyridin-3-amine | HCID 10329361 | — |
Reaction Steps
3-Nitro-4-methyl-2-pyridone was methylated with methyl iodide and reduced with zinc and acetic acid to give 2-methoxy-3-amino-4-methylpyridine. This material was coupled with 2-hexylthiodecanoic acid according to the procedure of Example 25 to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05362878 |
| Source dataset | uspto-grants-1994_11 |
| ORD ID | ord-f9cfc8b2369347209992578106dab733 |
| Source note | uspto-grants-1994_11 |