HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexylamine → N-(6-methylthioquinolin-5-yl)-2-hexylaminodecanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexylamine | HCID 8102 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | N-(6-methylthioquinolin-5-yl)-2-bromodecanamide | HCID 19027925 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | N-(6-methylthioquinolin-5-yl)-2-hexylaminodecanamide | HCID 19027888 | 88% |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
A mixture of N-(6-methylthioquinolin-5-yl)-2-bromodecanamide (200 mg, 0.47 mmol) and n-hexylamine (10 ml) was heated at 120° C. for 1 hour, cooled to room temperature, and chromatographed using 1:24:25/triethylamine:ethyl acetate:hexane as eluants to give the title compound as a pink oil (184 mg, 88% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05362878 |
| Source dataset | uspto-grants-1994_11 |
| ORD ID | ord-384cb1cac17043be8cbb7d36dedea91d |
| Source note | uspto-grants-1994_11 |