Sodium methanethiolate → HCID 21979919, compound

HRID 2379637Notes

Reaction equation

[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4](Br)=[CH:5][N:6]=[CH:7]2.[CH3:13][S-:14].[Na+]>>[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4]([S:14][CH3:13])=[CH:5][N:6]=[CH:7]2

Participants

Reactant 2

HCID 4378561Sodium methanethiolate

HCID 145800574-Bromoisoquinolin-5-amine

Product 1

HCID 21979919HCID 21979919, compound

Procedure

5-Amino-4-bromoisoquinoline (prepared according to the process described by Gordon et al., J. Het. Chem,, 4, 410 (1967)) was allowed to react with sodium thiomethoxide according to the procedure of Massie, Iowa State Coll. J. Sci., 21, 41 (1946) (Ca. 41: 3044 g) to give 5-amino-4-methylthioisoquinoline. This material was coupled with 2-hexylthiodecanoic acid (prepared by the procedures described in Examples 1 and 3) using the procedure described in Example 25 to give the title compound.

Sources & evidence

ORD record: ord-9c1b117738364334879b18d142afc038
Source dataset: uspto-grants-1994_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05362878

Reaction notes

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